I'm surprised this podcast hasn't been brought up on here much, considering it has a well written, diverse cast of characters.
Welcome to Night Vale takes place in a fictitious small American desert town and is narrated in the style of a radio news show explaining the weird, creepy, cute, silly things that happen in it.
It's like it Stephen King co-wrote A Prairie Home Companion.
It's free to download by its creators, here's the official site and first episode: http://nightvale.libsyn.com/webpage/2012/06